Molecules That Affect Megakaryocyte Development
نویسنده
چکیده
RESEARCH QUESTION Research into megakaryocyte activity has picked up in recent years, largely due to the introduction of more refined methods of studying these large multinucleated cells. More studies are being conducted on various molecules that may interact with and control megakaryocyte development, and subsequently their end-product, the platelets. The enzyme acetylcholinesterase (AchE) has been found to associate with megakaryocytes during their growth and development (Powers, 1989; Straneva et al, 1986). Another molecule, thrombopoietin [TPO], is also known to influence megakaryocyte development (Powers, 1989; Straneva et al, 1986). The focus of my research will be to investigate the effect acetylcholinesterase has on megakaryocyte biology in the presence and absence of thrombopoietin. My hypothesis is that acetylcholinesterase expression is enhanced in the presence of thrombopoietin, and this in turn influences the growth and development of megakaryocytes.
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